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A second-void sample adds an extra methodological step which may make sampling more difficult in large studies.
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Therefore, except for the number of rotatable bonds that may make the sampling and scoring of the ligand difficult with Glide, Surflex and Gold, there is no real influence of the properties of the protein or the ligand on the success of the four programs in finding the right pose.
The authors acknowledge that participants had to be judged mentally fit to consent, follow instructions and keep appointments, which may make the sample somewhat unrepresentative.
Weighting polling results by demographic characteristics may make the sample more representative, but there is increasing evidence that these weighting techniques will not remove all the bias that is introduced by missing so many voters.
The inherent magnetic fields of marine vehicles sometimes can locally disturb MMF, and this may make magnetometers sample the false information which is supposed to reflect MMF's real distribution.
For infants and young children, ease of urine collection (possible for extended periods of time) may make these samples the best available approach to capturing exposure variability of nonpersistent pesticides; additional validation studies are needed.
At some point, it may make sense to broaden sampling.
Veterans returning from recent wars with trauma, post-traumatic stress disorder, or other mental health conditions who were not part of this study given its FY2000 sampling may make similar choices in their preferred source of mental health care in the future, because VA is developing more expertise than community mental health providers in these types of treatment [ 49- 51].
Small design features or internal structures may make location of test samples more difficult.
An exploratory component to this research suggested that consumers perceive the concurrent elicitation of hedonic and CATA responses as easy, but that too many samples may make the task tedious.
Dead animals (for example, 'roadkill') or rapidly clotting samples may make blood clots the only DNA-source.
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CEO of Professional Science Editing for Scientists @ prosciediting.com