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Microglia are considered the resident immune cells of the central nervous system and while they may maintain tissue homeostasis they are also involve in inflammation and neurovascular dysfunction.
Furthermore, the sustained expression of miRNAs may maintain tissue homeostasis and only in circumstances when miRNA expression is altered, will pathological changes occur.
Manipulating the expression of exosomal contents related to angiogenesis, growth, proliferation, and self-renewal could potentially improve blood flow recovery, may maintain tissue growth, and thus could ultimately ameliorate organ function.
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Early fluid therapy may enhance or maintain tissue perfusion by increasing venous return and cardiac output.
Therefore, the scavenging of oxygen free radicals induced immediately after ischemia-reperfusion may not only maintain tissue viability but also enable sufficient contractile function of skeletal muscle.
In particular, NO release from the vascular endothelium in patients with heart failure may help to maintain tissue perfusion by reducing the vasoconstriction induced by various neurohumoral factors; moreover NO is able to modulate cardiac contractility [ 59].
Since MATN3 protein is an ECM protein, an accepted hypothesis is that its chondroprotective activity is due to its structural properties, which may help to maintain tissue integrity [ 47].
We suggest that GATA-4 and GATA-6 may maintain normal tissue renewal and differentiation in mature gastrointestinal mucosa and that alterations in their expression accompany premalignant and malignant changes in the gut mucosa.
Mechanical loading of joints due to exercise may be minimal but sufficient to maintain tissue homeostasis, it may be within the optimal physiological window and help maintain tissue homeostasis and produce positive tissue adaptations, or it may be strenuous, thus exceeding the physiological window and lead to disruptions of tissue homeostasis, leading to joint disease.
Recent international guidelines suggest that vasopressors may also be required to maintain tissue perfusion where fluid resuscitation itself does not achieve the expected goal [ 15].
Under physiological conditions, hexosaminidase cleavage products may thus play a protective role and maintain tissue homeostasis, while this homeostatic balance may be shifted during microbial infections.
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