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Quadratic programming solves the least squares problem (16) allowing to include irreversibility constraints (LS-MFA), but inherits the rest of drawbacks (and the chi-square tests may lose validity).
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Nowadays, if you say anything that is clearly true but upsets people, it starts to lose validity.
She may lose again.
Soon we may lose them.
The room he may lose.
"We may lose the case.
Some may lose their parliamentary immunity.
France may lose its AAA credit rating.
It's a battle I may lose.
They may lose or sacrifice their lives.
Jacoby & Meyers may lose this round.
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