Indeed, early initiation of trastuzumab has been associated with better outcome, while reducing anthracycline exposure may limit cardiac toxicity [ 37].
First, hepcidin-induced down-regulation of ferroportin sequesters iron in macrophages may limit its toxicity by reducing plasma "free" (e.g., nontransferrin bound) iron, particularly when plasma chelators are at their nadir between doses.
In some cells insolubilization may be conceived as a means to limit toxicity of abnormal proteins.
Further studies may assess selectivity of drug combinations in cancer vs. normal cells to limit toxicity, or pathogenic vs. commensal microbes (e.g., S. aureus vs. S. epidermidis) to preserve the microbiome under antibiotic treatment.
Such transport, would also presumably limit toxicity.
Although the immunogenic events arising from radiotherapy or chemotherapy can be successfully leveraged to support antitumour immunity, cancer vaccines offer more control over the specificity of the antitumour immune response, and may limit off-tumour toxicity resulting from on-target activity.
Thus, the liver may limit free cholesterol toxicity, but a consequence is that APOB-containing atherogenic lipoproteins are produced, which may, at least in part, account for the increased cardiovascular risk in patients with NAFLD [ 54].
Other approaches being explored include rainwater collection, novel filtration systems, chelation, and deep community wells, as well as the use of antioxidants, methionine (an amino acid), and other dietary supplements that may limit arsenic's toxicity.
Intermittent hormonal therapy is an approach that may limit the chronic toxicity of this systemic treatment in prostate cancer (Goldenberg et al, 1995; Higano et al, 1996) and is currently being evaluated in randomised trials.
