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On the other hand, higher levels of NAG are also found in various other conditions, such as urinary tract infections, which may limit specificity [ 64].
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CT is the most widely used imaging method due to its availability, although postsurgical changes and altered morphology may limit its specificity.
Such systems may not always be timely, they may have limited specificity, and baseline thresholds for indicator detection may be difficult to quantify.
Second, DECT may have limited specificity in knee OA.
The application of T-cell populations with unique TCR specificity (e.g. virus-specific T-cell clones) may limit the formation of mispaired TCR dimers.
Nevertheless, the limited sensitivity and specificity of standard microbiological culture techniques may limit their ability to detect the adherent bacteria responsible for PJI [ 11, 12].
Finally, the relatively low numbers of patients with metastases may limit the interpretation of comparisons of sensitivities and specificities.
However, we agree that complete substitution of DAP for adenosine may cause specificity to decline in certain sequence contexts, which may limit its usefulness in microarray applications.
The specificity of the subgroup of the patients with cirrhosis may limit the generalisation.
The specificity of miRs for IBD is not known and may limit their applicability as diagnostic biomarkers, but they could be used to monitor disease activity.
The receptor specificity of the viral HA is believed to be a factor that may limit the generation of human pandemic viruses from avian precursors [38].
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