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As nine of 12 pituitary carcinomas were devoid of clusterin expression, this protein may limit proliferation of benign adenomatous pituitary cells.
MiR-424 and miR-503 can induce G1 arrest in THP-1 cells [ 14] and may limit proliferation in pilocytic astrocytomas.
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Intel, for example, has a handle on the new technology and has the market clout to get its WiMax silicon into devices, such as laptops and handheld computers, though power consumption requirements may limit WiMax proliferation in the smallest handheld devices.
These results indicated that TGF-β signaling may suppress secretion of HGF from fibroblasts to limit proliferation of adjacent epithelial cells in normal condition.
Inhibiting telomerase activity in tumor cells may increase the number of damaged telomeres and thereby limit proliferation.
Diverse modes of regulation may also reflect the importance of having adequate checkpoints to limit proliferation.
While other types of stimuli can similarly limit proliferation, telomere attrition is one of the best characterized stimuli and may contribute to aging in some human tissues (Campisi and D'adda Di Fagagna 2007; Jeyapalan and Sedivy 2008).
The TNP-470 inhibition of microvascular proliferation may limit the development of collaterals that communicate with new feeding arteries.
In mouse models, ovarian hormones contribute significantly to mammary gland carcinogenesis [ 16]; however, differences between mouse and human mammary gland anatomy, development, and/or hormonal control of proliferation may limit the translational relevance of targets identified in the mouse for estrogen and progestogen function.
Senescent ECs showed a reduced proliferation that may limit the capacity to form new vascular structures.
Short telomeres may limit normal stem cell division by inducing proliferation arrest and select for stem cells with dysfunctional telomeres and defective DNA damage responses that are prone to chromosomal instability.
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