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Aging of these tissues may limit lifespan.
It is generated by several reactive oxygen species (ROS), may limit lifespan and has been related to several human diseases.
Because cells with defects in DNA replication, DNA repair and transcription elongation may manifest an rDNA instability phenotype and lifespan shortage without ERC accumulation (Heo et al. 1999; Hoopes et al. 2002; Merker and Klein 2002), it may be postulated that rDNA instability itself may limit lifespan rather than ERC formation (Kobayashi 2008).
Similar(57)
These data indicate that although single-gene effects may significantly affect lifespan (Friedman & Johnson, 1988a; Guarente & Kenyon, 2000), molecular stochastic processes also have to be taken into account as significant factors that limit lifespan in individual animals.
But although molecular damage accumulates, it does not necessarily limit lifespan, particularly if other causes limit life span.
The experimental data gathered all along the 4000 h of stress accumulated up to now suggest the presence of multiple degradation mechanisms that may limit the useful lifespan of the light-emitting diodes under test.
Even though rapamycin has been shown to increase lifespan and to protect against cancer, side effects such as dyslipidemia may limit its clinical usefulness.
Such forces may limit creative investigation.
Let other men seek immortality in progeny; music has no limiting lifespan.
Meanwhile, energy storages have limited lifespan.
Some functions associated with proteins from the insoluble fraction have been previously implicated in limiting lifespan.
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