Sentence examples for may limit dose from inspiring English sources

Mechanism-based side effects may limit dose escalation further, resulting in suboptimal target engagement and impaired efficacy.

Clinical studies suggest that combined targeting of HER2 and VEGFR may be an effective strategy as treatment for HER2-overexpressing breast cancer but that toxicity may limit dose for some combinations.

This helps separate the therapeutic effect of MSF in the brain from the undesired peripheral cholinergic side effects that are commonly experienced with the currently available short-acting AChEIs which also may limit dosing to what can be tolerated by the patients.

34– 36 Although it is usually recommended that the statin dose should be up-titrated before a second agent is added if greater LDL-C lowering is needed, actual or potential adverse statin effects may limit the dose that can be used, in which case the addition of colesevelam significantly adds to the effect of low dose statins.

Gastrointestinal side effects may limit the dose that can be used.

Although well tolerated by the majority of patients, docetaxel toxicity may limit the dose which can be administered.

The main adverse reactions to oral iron are gastrointestinal and may limit adherence and dose [ 12].

Highly conformal planning using multi-leaf collimators (MLCs) which can be adjusted during the treatment may limit the radiation dose to the bowel and other normal structures, thereby potentially reducing acute and late gastrointestinal side effects [75 77].

Radiotherapy, an important modality in treating cancers, induces serious side effects that result from radiation-induced damage to normal tissues and may limit the therapeutic doses of ionizing radiation and thereby restrict the efficacy of the treatment (Baliga et al., 2012).

The relevance of this phenomenon to critically ill patients who may receive limited dosing has not been determined, but it may be important for certain high risk patients.

Larger-sized patients generally require higher tube voltage settings which may limit any contrast media dose reduction.