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We conclude that following intradermal infection, sequestration of Bartonella spp. in tissues may limit diagnostic detection of these bacteria in dog blood samples.
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This high variability may limit their diagnostic value.
If this high rate of colonization translates to the presence of antigen in the urine it may limit the diagnostic utility of the BinaxNOW test in certain populations.
The heterogeneity of DKK-1 protein expression within the tumour may limit the diagnostic value of DKK-1 assessment from biopsies of the primary cancer and also explains the lack of correlation between tumour and serum DKK-1 levels.
Thyroid aspiration may yield limited diagnostic material, insufficient for additional testing.
Additionally, there tends to be a lower reporting of glaucoma in Africa compared to other blinding conditions in global burden data because surveys in Africa may have had limited diagnostic capacity for glaucoma [ 9].
The specificity of miRs for IBD is not known and may limit their applicability as diagnostic biomarkers, but they could be used to monitor disease activity.
However, these assays are reported to be low in specificity and sensitivity, and clinically, the low sensitivity of these diagnostics may limit the usefulness for reliable detection of influenza A (H5N1) virus in humans [ 9].
The poor availability of positive control materials in diagnostic laboratories may limit the public health response.
Furthermore, while we identified differences between BD and unipolar depression groups, uncertainty regarding diagnostic precision may limit the interpretation of results.
Firstly, the majority (77.6%) of patients underwent diagnostic colonoscopy, which may limit its extrapolations.
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