Sentence examples for may lie upstream from inspiring English sources
This finding suggests that extrinsic signaling pathways may lie upstream of the network of known transcription factors that regulate pluripotency.
Gab2 may lie upstream or downstream of STAT5 to promote hematopoiesis or it may function solely through ERK or AKT.
In this vein, our observation that the pro-exocrine bHLH factor Ptf1a can induce Math6 expression in vitro (Figure 8) supports the notion that this bHLH factor may lie upstream of Math6 in the exocrine cell lineage [37], and suggests a general paradigm in which Math6 is induced broadly by class II bHLH factors that initiate differentiation in different cell lineages.
Furthermore, Rac1-stimulated increase in expression of p66shc is dependent on intracellular ROS suggesting that ROS generated by Rac1 activation may lie upstream of p66shc [ 9].
Therefore it appears that the lesion preventing PG accumulation may lie upstream of a putative step for catalyzing 2-hydroxylation of benzyl/cinnamyl ring precursors.
The inhibition of autophagy leading to the accumulation of autophagy substrates and receptors may lie upstream of proteasomal dysfunction and programmed cell death in certain cases.
For ϕBT1, such a promoter could obviously be provided by the asRNA; for ϕC31, the asRNA promoter may well lie upstream of the integration site, but asRNA transcript levels were more abundant downstream of this region.
The similarity we observed between activity for forced and free choices suggests that the forced-free distinction may lie largely upstream of the motor cortices.
Since domains acting to strongly silence cIRK1 expression in DF1 cells were missing in the 5'-flanking region characterized in this study, additional distant control regions may lie further upstream, downstream, or in the intronic sequences.
One may presume that since pre-GM cells lie upstream of GMPs their transcriptional programs should have diverged less from multipotent cells that retain both GM and E potential.
They may bind directly to special "promoter" regions of DNA, which lie upstream of the coding region in a gene, or directly to the RNA polymerase molecule.
