Sentence examples for may involve upregulation from inspiring English sources
One mechanism may involve upregulation of specific host receptors targeted by bacteria.
These effects may involve upregulation of anti-inflammatory factors and subsequent downregulation of IL6.
These findings suggest that progression of breast cancer from hormone dependence to hormone independence may involve upregulation of EGFR.
These effects may involve upregulation of anti-inflammatory mediators and antioxidants capacity and subsequent downregulation of IL-6.
Reduced Klotho levels may involve upregulation of the renal renin-angiotensin system (RAS) pathway, since angiotensin II negatively regulates the renal expression of Klotho in CKD [ 44– 44].
The mechanism underlying the tumour-suppressive activity of α7β1 remains unclear, but may involve upregulation of inhibitors of cyclin-dependent kinases and Rac family small GTPases (Ref. 52).
A function for Stat5a in tumor initiation may involve proliferative upregulation of cyclin D1 [ 16, 17] and antiapoptotic effects, for instance, through upregulation of Akt1 [ 18] or induction of Survivin [ 19].
Our results suggest that these responses may involve the upregulation of genes involved in the synthesis of membrane transport and virulence proteins and also proteins involved in the maintainanceof the integrity of the cell membrane.
The molecular basis for acquired resistance to Herceptin® is poorly understood, but may involve HER2-independent upregulation of phosphoinositide 3 (PI3) and mitogen activated protein (MAP) kinase pathways, possibly through upregulation of insulin-like growth factor-1 receptor (IGF-IR) or EGFR ligand activation [7].
Surprisingly, the mTOR inhibitor rapamycin enhances differentiation of Treg cells by a mechanism that has yet to be fully understood, but which may involve Foxp3-dependent upregulation of Pim2 [29], [30], [30].
Mechanistically, survivin upregulation may involve nitric oxide (NO -induced Akt sigNO -inducedenhAkted expresignalingthe endothelias NO synthasenhancedosphorylatexpressione detectable in sofe surviving-positheendothelials.
