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Thus, the absence of MMP-8 has multiple consequences for angiogenesis, innate immune responses and metastasis that conspire to promote tumor growth and malignancy, and which may involve systemic disturbance of the protease web.
The mechanism of action underlying this increase in OC numbers followed by their subsequent apoptosis remains to be resolved and may involve systemic factors, local factors or a combination of the two.
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The in vivo regulation of androgen receptors by pharmacologic doses of estrogens may thus involve systemic and posttranscriptional effects that are not observable in terms of Ar mRNA levels in isolated mesenchyme cells.
Brucellosis is a systemic disease and may involve any organ system.
As presented in figure 1, likely mechanisms by which sub-daily levels of fine particles (PM) induce acute cardiovascular effects may involve the autonomic nervous system, systemic inflammation, vasomotor dysfunction and/or thrombogenesis [ 1- 3].
Patients with low GCS (3 to 5) show global brain, brainstem or reticular system damage [ 23], which may involve the dysfunction of systemic homeostasis.
Systemic anaphylaxis may involve the entire body, with shock as a key feature.
Importantly, progressive systemic sclerosis may involve interstitial lung disease (ILD) resulting into a restrictive lung function pattern abnormality [ 1].
Candida species produce diseases that range from non-life-threatening superficial to systemic infections that may involve virtually any organ [2].
The aberrant systemic arterial supply may involve a single or multiple vessels, and the latter accounts for 15 20% of pulmonary sequestration cases [ 18].
We want what's best for our kids; but some of that may involve things beyond the scope of our own family—systemic changes in schools, for example, that could lead to better psychological health for teens.
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