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Altered protein modifications in response to alcohol exposure also may involve proteins other than histones that contribute to other manifestations of FAS, including proteins involved in insulin signaling.
Direct inhibition of transcription may be through blocking the binding of transcription factors to promoters containing methylated CpG sites (9), whereas indirect repression may involve proteins such as methyl CpG binding protein 2 (MeCP2) that specifically bind to methylated DNA via a methyl CpG-binding domain (MBD; ref. 10).
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These data demonstrated that Ad35 cell entry is CAR independent, and may involve protein(s) expressed on most human cells.
The latter may involve protein-protein and protein-DNA interactions among ERα, NM23, 17β-HSD1, AR, cathepsin D and other genes and proteins.
Interestingly, such would indicate that RA may involve protein networks that interplay with both p53 signaling (has04115: p = 2.34 × 10−5) and leukocyte transendothelial migration (has04670: p = 5.75 × 10−4).
Additional mechanism for the preferential killing of HIF-α-positive cells by EMCV may involve protein expression from the virus' internal ribosome entry site (IRES).
The interaction of pathogen elicitors with host receptors (many of which may be encoded by resistance genes) likely activates a signal transduction cascade that may involve protein phosphorylation, ion fluxes, reactive oxygen species (ROS) and other signaling events.
Among these, the proinflammatory cytokine IL-1 elevates pHi in T cells through activation of the Na+/H+ antiporter by a mechanism that may involve protein kinase C (Civitelli et al, 1989).
The impact of cyanobacteria on respiratory symptoms in atopic individuals is worthy of investigation, and may involve protein allergens and cyanobacterial endotoxin from both toxic and non-toxic blooms.
The interaction of pathogen elicitors with host receptors likely activates a signal transduction cascade that may involve protein phosphorylation, ion fluxes, reactive oxygen species (ROS), and other signaling events [ 3, 4].
The mechanism of SasC-mediated biofilm accumulation is not known yet and may involve either protein-protein interactions conferred by the N-terminal SasC domain or protein-carbohydrate interactions conferred by the FIVAR motif.
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