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Certain mechanisms may involve poor drug solubility, poor permeability, degradation (enzymatic/nonenzymatic), and first pass hepatic metabolism [ 3].
These results further suggest that the Taxol resistance in HCC may involve poor uptake of Taxol because of the barrier in solid tumour as well as the intrinsic factors that regulate the metabolism of Taxol and cellular response to Taxol.
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The reasons for the association between social deprivation and poor outcomes are complex and little understood but may involve poorer access to transport, being employed in manual work and how people communicate (Dixon et al, 2003) and possibly concomitant morbidity (Wrigley et al, 2003).
This discrepancy may involve either poor protein stability or the cytotoxic nature of His-TAT-Apoptin when present in BL21 DE3) and BL21 DE3 Codonplus-RP.
In actuality, the addition of components to an evolving organ may occur in series (i.e., one at a time) and may involve a relatively poor fit at first.
Measuring Pro-Poor Targeting may involve complex and multidimensional considerations for identifying poor patients [ 27].
For poor women, the abortion may involve a choice between continuing an unwelcome pregnancy or feeding and buying medicine for the children they already have.
Although not yet examined, a likely mechanism of poor sleep in HF may involve structural and functional brain abnormalities.
Other human studies may involve for instance children from countries with poor nutrition that are adopted by families in economically prosperous countries.
It is also possible that the Pleistocene refuge in northwestern France may involve caves, as suspected in Belgium for other poor cold-hardy animals and deciduous trees [ 18].
The recommended choices may involve tradeoffs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com