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It may involve patients and doctors working together to redesign services, improve a hospital's performance or develop self-management programmes for chronic disease.
These studies may involve patients who are in advanced stages of their disease, whose life expectancies are limited [ 2], and for whom research raises distinct ethical, as well as logistical challenges.
As will be discussed later in this paper, such studies may involve patients with newly diagnosed, potentially curable cancers and toxicity end points may be reached months (or even years) after completion of treatment.
The results obtained by our study cannot be considered definitive but may help planning an experimental, controlled, randomised study which may give more robust results, and may involve patients of different age groups with different doses and administration schemes.
In contrast, the lower end of the therapeutic scale may involve patients only receiving brief instruction in the therapist's office and then being sent home to practice the new skills by themselves with only a printed sheet of verbal instructions provided by the therapist to consult (sometimes with model drawings).
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Some organ allocation organisations may involve patient representatives, however the extent to which patients are involved and their actual contribution is unclear.
ICGA gives qualitative and functional information and may involve patient discomfort since it requires dye injection, which has the potential to induce adverse reactions [ 2, 3].
Another explanation may in involve patients' perception of their risk for cardiovascular disease.
These memories are frequently described by patients as very vivid, realistic and frightening and may even involve patients thinking that nurses or doctors tried to kill them [ 6].
This may involve telling patients that a DARE is due at their next visit or give them the option to clean themselves before doing the DARE.
Additionally, as patient related barriers were the most perceived barriers across recommendations, it may be useful to involve patients in the process of guideline development as well as in the actual decision making process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com