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This inefficiency may involve irreversible changes in the epigenetic program of the cultured cells.
The molecular mechanism by which antagomirs block the miRNA function remains to be elucidated, but it may involve irreversible binding to the targeted miRNA.
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While there is some evidence that this switch may involve an irreversible change in the developing carcinoma cell itself, it is also plausible that the cell experiences a stress response to the lack of oxygen (hypoxia) and other nutrients within the microenvironment of the developing tumour.
We proposed that the antibiofilm activity of A101 may be involved irreversible binding or adsorption in S. aureus RN6390, and reversible in P. aeruginosa FRD1.
The global sort is hard to pin down, but can involve irreversible changes.
Filter out those metabolic pathways that involve irreversible reactions applied in the reverse direction.
The data indicate that, while alkane conversions at low temperatures (about 300°C or less) may involve reversible adsorption, irreversible adsorption of the alkane is the rate determining step at higher temperatures representative of naphtha reforming.
These effects are irreversible and may involve an instructive mechanism or the selective proliferation of myoepithelial cells.
It is suggested that this step may involve other tissue proteins apart from collagen and that the irreversible nature of fibrosis can be explained by the formation of strong intermolecular crosslinks between different proteins.
The recommended choices may involve tradeoffs.
It may involve a bit of superstition.
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