Exact(2)
These results suggest that insertion and deletion events, which may involve genomic rearrangement and recombination, are more likely in the upstream region than in the coding regions of genes.
This suggested that NOTCH1 signaling is a fundamental PGL pathway and that its activation may involve genomic amplification along with other mechanisms.
Similar(58)
Schizophrenia is a multifactorial and highly heterogeneous disorder and may involve both genomic and environmental contributions [50].
Based on evidence collected thus far, cholesteatomas clearly exhibit clinical features similar to those observed in neoplasms, indicating that the dysregulation of cell growth control may involve internal genomic alterations.
Previous studies suggest the virulence loss mechanism may involve post-genomic modification.
These findings raise the possibility that EDC activation of extranuclear estrogen receptors may involve a nongenomic to genomic signaling cascade via kinase-induced activation of the transcription factor, CREB.
More simple schemes to help define epistasis may involve interactions derived from genomic and proteomic data, which can allow for decoding transcriptional and posttranscriptional interaction networks (Johnson et al. 2004).
Duplication events may involve either the whole genome (whole-genome duplication [WGD]) or single genes or genomic regions (segmental duplication).
2 Driver genomic events may involve targetable kinases, including but not limited to EGFR and anaplastic lymphoma kinase (ALK). 2 Better understanding of these driver mutations has allowed development of small-molecule tyrosine kinase inhibitors (TKIs) that are being used as therapeutic agents.
The apparent mitonuclear decoupling in these coastal populations presents an intriguing pattern that may involve distinct oceanographic and environmental mechanisms influencing different genomic partitions in N. scabrosus.
Genomic variations within a species may involve changes as small as a single nucleotide to as large as microscopically visible chromosome segments, even whole sets of chromosomes.
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