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The search has stalled badly; while these disorders may involve genetic disruptions, no underlying patterns have surfaced — no single gene or genes that account for more than a tiny fraction of cases.
The reasons for this phenotypic dichotomy are currently unknown but may involve genetic backgrounds and environmental modifiers.
Compartmentalization may involve genetic drift and founder effects [ 23], and/or being a consequence of different selective pressures [ 12].
The physiopathology of AN has not yet been fully determined, and may involve genetic, neurobiological, and environmental factors [ 2, 3].
HAART-related dyslipidemia may involve genetic predisposition, as not all patients taking HAART develop comparable metabolic disturbances [ 48].
This relief, which may involve genetic or epigenetic events [ 90], is also described as field cancerization [ 91].
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Because of logistical constraints, investigators often employ non-invasive 'captures' that may involve 'genetic' or 'photographic' sampling in such cases.
Obesity must occur through genetic expression, probably of a very large number of genes, and some expression patterns may not even involve genetic differences among individuals.
Complex diseases or phenotypes may involve multiple genetic variants and interactions between genetic, environmental and other factors.
The development of this EBV-associated cancer may involve cumulative genetic and epigenetic changes in a background of predisposed genetic and environmental factors [ 3, 4].
Thus, the etiology of CNS tumors is complex and may involve several genetic and/or environmental factors that may act differently according to histological subtype.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com