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Others have also found that Med and Mad induce such phenotypes upon misexpression, and these effects may involve enhanced stabilization of endogenous Mad [32].
Thus, improved expression of genes involved in ribosomal protein biosynthesis and mitochondrial biogenesis in skeletal muscle of PCOS patients after long term pioglitazone therapy may involve enhanced mTOR signaling mediated in part by an improved anabolic action of insulin.
Such alteration may involve enhanced CD109 protein synthesis and/or decreased CD109 protein degradation.
The etiology of chronic, unexplained fatigue, CFS, and fibromyalgia remains unclear [ 7], but recent work suggests that these disorders may involve enhanced interoception [ 14, 15].
These may involve enhanced metabolism of glucose and the closure of ATP-sensitive K+ channels, followed by limited membrane depolarisation [ 13, 14].
Recent studies have indicated that the Ala12 allele mediated improvement in insulin sensitivity may involve enhanced suppression of lipid oxidation, which permits more efficient glucose disposal (9).
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Surprisingly, overexpression of wild-type seipin specifically inhibits TAG synthesis and LD formation in non-adipocytes, which may not involve enhanced lipolysis [ 48, 53, 59].
In our analyses, we found no evidence for broad-spectrum enhanced protection against stressors under DR. Thus, the mechanism for increased longevity under DR may not involve enhanced resistance to stress.
Circulating autoreactive leucocytes may initially home to peripheral nerves by a mechanism that involves enhanced local gradients of chemokine expression (Zou et al., 1999; Kieseier et al., 2000).
This may involve both enhancing activation status of immunocompetent cells leading to increased immune surveillance and inhibiting low grade inflammation.
88, 123 An additional mechanism by which BDNF may mediate beneficial effects of DER on cognition involves enhancing cellular energy metabolism.
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