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Although the specific mechanisms leading to MOH remain still unknown, several studies suggest that MOH may involve amplification processes, including descending facilitation and "central sensitization", and an increased excitability of spinal and medullary dorsal horn neurons resulting from a continuous input exerted by C-fiber nociceptors [3, 4].
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This suggested that NOTCH1 signaling is a fundamental PGL pathway and that its activation may involve genomic amplification along with other mechanisms.
Our results also suggest that codon usage of the selection marker should be considered for applications that may involve gene amplification and serum free suspension culture, since the overall codon usage and thus the general expression and regulation of host cell proteins may be affected in the surviving cells.
DNA amplification may involve one gene or several genes belonging to a same locus.
An overview of the genomic architecture of gene fusions reveals that fusions may result from insertion, deletion, inversion, or tandem duplication or amplification, and may involve the same chromosome (intra-chromosomal) or different chromosomes (inter-chromosomal) (Fig. 2).
The pooling of national or global patient resources should allow the realisation of prospective clinical trials (that stratify for HER2 gene amplification or EGFR expression) for patients with type II EC that may involve HER2 and EGFR tyrosine kinase inhibitors in well-defined subsets with HER2 gene amplification or EGFR expression.
In the present study, distal boundaries of amplicons in the majority of ESCC cell lines and primary tumors with 11q13 amplification were clustered within 67-72 Mb region of 11q13.3, which may involve FRA11H breakages for these cases.
It may involve a bit of superstition.
Again, that may involve extra capital.
The recommended choices may involve tradeoffs.
That may involve difficult choices.
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