Sentence examples for may involve activation from inspiring English sources

Apart from the direct cytotoxic effects of TNFα against tumors, its antitumor activities may involve activation of different neutrophil functions, alteration of endothelial cell functions and increased production of IL-1.

These findings suggest that the antiepileptic effects of LFS may involve activation of GABA BZD and endogenous opioid systems.

Loss of estrogen-dependent cardiovascular protection diminishes endothelial function, and may involve activation of the renin-angiotensin system (RAS).

In certain conditional transgenic models, reactivation of c-Myc after transient disruption restores tumor growth [57], which may involve activation of dormant cancer stem cells.

In the models of R6/2 and YAC128 mice, we show that DMF exerts beneficial effects and preserves motor functions as well as intact neurons which may involve activation of the Nrf2 signalling pathway.

TRPV1 receptors are expressed in human prostate tissue [50], [51], so in theory some of the protective properties of AEA may involve activation of these receptors, given that in other cancer cell types, AEA can produce apoptosis via such a mechanism [52].

The mechanisms responsible for the increase of the sympathetic drive remain unclear but may involve activations of pulmonary neural reflex arcs and direct effects of pollutants on cardiac ion channels [ 89].

Thus, the cell apoptosis induced by SSd and radiation may involved activation of the p53/Bcl2 pathway.

Other GPCRs have been shown to activate ERK in a Gi and ras-dependent mechanism, which may or may not involve activation of PI3 K (Della Rocca et al, 1999).

Additional studies have also implicated direct binding to the extracellular matrix (ECM) and transfer to the cell membrane via laminin-5 [7], a process which may also involve activation of and transfer along cell surface filopodia [8], [9].

Given the importance of IL-12 to IFNγ production [49], [60], [61] and the observed correlations of TLR-mediated IFNγ protein with IL12B message, TLR8-mediated IFNγ responses may also involve activation of IL-12B (that encodes for IL-12p40 [49]. IL-12p40 [49]