A possible scenario for the involvement of both proteoglycans in breast cancer progression may involve the accumulation of both versican and decorin by stromal fibroblasts in response to estrogens, growth factors and cytokines.
The mechanism of resistance may involve reduced accumulation or increased cytoplasmic detoxification that cause insufficient platinum to reach and bind to the target DNA or increased DNA repair/tolerance of platinum DNA adducts that lead to cell survival.
Taken in total, these findings suggest that MTAP may exert its tumor suppressor effects via two different mechanisms; an enzyme-dependent mechanism that may involve the accumulation of the MTAP substrate MTA, and a nonenzymatic mechanism that predominates in HT1080 cells.
The development and progression of ESCC stages, including single hyperplasia and single squamous metaplasia, atypical hyperplasia and allotype squamous metaplasia, in situ carcinoma, infiltrating carcinoma, and metastatic carcinoma, may involve the accumulation of multiple genetic alterations over a long period of time [ 40].
Further extending the reflection about the very nature of information may be highly relevant to the processes that involve accumulation of biological information.
Interestingly, it was observed that the accumulation of ZmZIP5 was dramatically up-regulated during the development of endosperm and reached a peak on 19 DAP, though its expression was decreased on 21 DAP, which suggests that ZmZIP5 may involve in the accumulation of nutrient substance at early grain filling stage.
High C. moseleyi densities identified in saline decaying seaweeds are intriguing, and may involve osmoregulatory adjustments including accumulation of osmoprotectants.
Firstly, the dh404-induced Nrf2 nuclear accumulation may involve other regulator mechanisms, such as nuclear dissociation of Nrf2 with Keap1or nuclear turnover of Nrf2 [39], [39].
The hepatic response to stress may involve the synthesis and accumulation of HSP70s [ 18, 19].
These data indicate that, while inherent resistance to ADR may be multifactorial, one possible mechanism of resistance in human glioma may involve changes in drug accumulation and/or binding as has been seen in animals models.
