Sentence examples for may introduce mutations from inspiring English sources

Additionally, inactivation of DNA dioxygenases may introduce mutations preserving selected phenotypes.

In contrast, too much recombination breaks apart advantageous allele combinations, threatens genomic integrity, and may introduce mutations at hotspots (Kauppi et al. 2004; Coop and Przeworski 2007; Rattray et al. 2015).

The results of the experiments suggest Pol ι, Rev1, and Pol κ may cooperate in bypassing M1dG residues and may introduce mutations that are observed in cellular mutagenesis experiments.

AID-mediated mutagenesis in B-1a IgVH may occasionally introduce mutations elsewhere in the genome that facilitate dysregulated growth and neoplastic transformation, e.g., B-chronic lymphocytic leukemia (B-CLL) (Stall et al., 1988; Kipps et al., 1992; Phillips and Raveche, 1992).

WGA may introduce artifact mutations [17], which cannot be distinguished from mutations that occurred in the mouse.

In addition, replication errors due to DNA damage may introduce irreversible mutations.

Viral vectors need to be incorporated in to host chromosome and they may introduce random mutations as viral DNA cannot be specifically targeted.

A plausible mechanism proposed recently is that bacterial genomes have different Polymerase III mutator genes that may introduce GC-biased mutations depending on the alpha subunit isoforms [ 59].

NHEJ can also introduce mutations during repair.

Furthermore, incorporating EOAD cases may introduce subjects with mutations in APP, PSEN1, and PSEN2.

Quiescence, also known as dormancy, warrants the genomic integrity of HSCs, as frequent chromosomal replications may introduce oncogenic DNA mutations.