A low probability of detection may introduce considerable error into distribution patterns, resulting in inaccurate ecological conclusions.
The classical two-field, two-fluid model treats each phase as a whole, which may introduce considerable uncertainties when a phase is comprised of significantly different forms, e.g., liquid droplets and liquid film, and/or vapor bubbles and continuous vapor core.
A potential weakness of QN is that in parts of the distribution with few values (and therefore relatively large interquantile differences), it may introduce considerable changes.
There is evidence that irrational prescribing in primary care may introduce considerable harm, resulting in a number of hospital admissions due to adverse drug events [ 4].
However, the "seed-based" methods have several drawbacks stemming from an inherent limitation: these methods rely on known disease genes, which are incomplete in some studies and may introduce considerable bias.
In these cases the results have to be viewed with care, as ICRP 106 [ 3] mentions in the section "Uncertainties in absorbed dose estimates" that intersubject variability may introduce considerable variation in accumulated activity.
