Focusing on first-order neighbors is not enough when it is known that, through the propagation of biological signals, a gene may interplay with its high-order neighbors.
Small net improvements of cardiac output may interplay with a lowered rate of cognitive deterioration seen with this approach as a mode of cardiac revascularization, but controversy attends these considerations.
Strikingly, in the co-culture of CMT93 and mouse peritoneal macrophages, CMT93 cancer cells produced 26.4-fold more CCL20 than macrophages at mRNA levels, suggesting that macrophages may interplay with cancer cells for production of CCL20 in the tumor microenvironment (Figure 3F).
This nuclear ERα may interplay with ERβ and there is emerging evidence that membrane-localised ERα may also have a role.
As a further complication, the diagnostic criteria for some of these behaviourally-based conditions are more subjective than for medical conditions, which may interplay with desire to avoid stigma in using certain diagnostic codes.
We anticipate that the addition of vector control and vaccines may interplay with MDAs in interesting ways as prevalence is reduced close to 0, and future work will situate drug campaigns in the context of other ongoing interventions.
