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Thus, although rapid dephosphorylation of Stat3 by three PTPs may initially serve to protect skin from UVB-mediated carcinogenesis, this mechanism is overcome by other effects induced by UVB that ultimately lead to activation of Stat3 and tumor development [8], [9], [14], [15].
Thus, insertions may initially serve as nearly neutral evolutionary experiments.
It may initially serve as a fatty acid sink to circumscribe the formation of toxic lipid species and subsequently foster cardiac damage.
In the pressure-loaded RV, a myriad of cellular changes takes place that may initially serve as adaptive remodeling, but are also present in the failing RV (Fig. 2).
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Shisunaga, or Susunaga, the founder, was of obscure origin and may have initially served as Magadhan viceroy at Kashi (Varanasi).
Coinciding with the rise of monumental architecture in Greece, the construction of the Diolkos may have initially served particularly for transporting heavy goods like marble, monoliths and timber to points west and east.
The pilot hopes to initially serve about 200 people.
3. Waitlist Control: Treatment delayed; subjects initially serve as No Treatment Controls.
A Lutheran congregation may have formed in Madison in about 1875, although early records are incomplete; the congregation was initially served by the pastor of a Lutheran church in Green Garden Precinct, located about seven miles (7 mile) southwest of Madison.
Land, which initially served only individual needs, came to be the fundamental source of economic enterprise.
He initially served as Lady Thatcher's chief economic adviser between 1981 and 1984.
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