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These data suggest that resveratrol and/or TRAIL may inhibit prostate cancer metastasis by inhibiting MMP-2 and MMP-9.
These results indicate that DCPA may inhibit prostate cancer cell migration, proliferation, and HIF-1α expression through multiple signaling pathways.
Thus, the results suggest that salinomycin may inhibit prostate cancer stem cells by impairing the redox control.
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Moreover, HS-1793 may inhibit human prostate cancer progression and angiogenesis by inhibiting the expression of hypoxic condition induced HIF-1 α protein and vascular endothelial growth factor (VEGF).
4 Additionally, SRC kinase activity has been found to be upregulated in a number of preclinical models of CRPC; 5, 6 as such, a potentially effective strategy to inhibit prostate cancer growth and metastasis may be to target SRC kinase.
Clusterin expression is enhanced in human prostate cancer, and antisense oligonucleotides targeting clusterin inhibit prostate tumorigenesis [56].
Our xenograft models of prostate cancer confirmed the capability of let-7a to inhibit prostate tumor development in vivo.
Similarly, dutasteride, an analog of finasteride, was also reported to significantly inhibit prostate cancer development [3].
These studies suggest that TSA and sodium butyrate inhibit prostate cancer cell growth by inducing apoptosis.
These results suggest that AdPSAE1 is able to specifically inhibit prostate tumor growth in vivo.
As mentioned above, a recent study suggested that regulated over-expression of RASSF1C may inhibit the growth of prostate cancer (LNCaP) and renal cell carcinoma (KRC/Y) cells [ 15].
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