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However, it may inhibit functions of the monomeric form of AnxA2.
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At the molecular level, Mab21l2 may inhibit function of BMP4 signaling via direct binding to Smad1 [76].
Iron at very high levels is toxic and may inhibit enzymatic functions (WRC 2003) in aquatic organisms.
So, we hypothesized that CP+dsDNA treatment may also affect TISC population, and this may inhibit their function or destroy these cells, which can be manifested as inhibition of tumor graft growth.
Instead, it interacts preferentially with the zinc finger domain of another, nonubiquitinated Rad18 and may inhibit Rad18 function in trans.
On a cellular level, the bisphosphonates target the osteoclasts and may inhibit their function as follows: hindering the osteoclast recruitment; reducing the osteoclast life span [10, 11].
BAG2 may inhibit CHIP function by disrupting the interaction between CHIP and its E2, UbcH5b [33], [33].
Second, the presence of RNA upstream of an IRES may inhibit its function [45].
We have previously suggested that TNF-α may inhibit the function of MSCs when the cells were injected on day 21 [16].
It can be attributed to several factors, including: (1) SYN may inhibit proteasomal function and induces protein degradation failure when overloaded intracellularly; (2) SYN can be modified into more toxic forms by peroxynitrite, reactive oxygen species and/or other endogenous oxidative compounds, and aggravates nigrostriatal degeneration.
These suppressive monocytes may inhibit the function of therapeutic DC.
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