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The IGF C-1245T (rs35767) and the myostatin (MSTN) Lys(K -153Arg(R) genetic polymorphism may influence sK -153Arguscle phenotypes and athletic peRformance.
However, dysfunctional regulation of FAPs mediated by changes in IL-4 signaling may influence skeletal muscle homeostasis.
It is possible, therefore, that calcium intake in childhood may influence skeletal growth and pubertal development in adolescence.
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Nutritional deficiencies (insufficient intake of energy, proteins, and micronutrients) may influence the skeletal as well as the dental development because the role of nutrition for oral tissues may not be different from that for other tissues and organ systems.
Estrogen has been suggested to influence skeletal homeostasis by both increasing the sensitivity of the feedback control system for skeletal rigidity and acting directly on bone surfaces.
The inclination of the maxillary posterior occlusal plane during growth and development can influence skeletal pattern and malocclusion type.
Gene-gene interaction is known from mouse models to influence skeletal development significantly [ 55] and is thus likely also to contribute to human skeletal development.
27 29 However, it is still unknown whether and how the pulsatile PTH secretion may influence these extra-skeletal targets.
Air pollution may influence the development of skeletal malformation through various biologic mechanisms, including hemodynamic, anoxic events, oxidative stress, and toxicity to certain cell populations during pregnancy (Ritz et al. 2002).
We also tested if DNA methylation around the transcription start of ATP5O may influence the mRNA expression in skeletal muscle.
Table 4 shows additional parameters, such as storage time and handling, which besides the age of the skeletal material may influence the ability to obtain authentic ancient DNA [16], [37], [38].
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