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Besides the indication for statin use, other possible confounding factors include other medications not included in this study, which may influence relapse, as well as lifestyle differences such as diet, exercise, alcohol and tobacco intake, socioeconomic status, and educational levels.
Retinoids are susceptible to oxidative metabolism, and the extensive metabolism of all- trans-retinoic acid (ATRA) in acute promyelocytic leukaemia (APL) may influence relapse rates (Muindi et al, 1992).
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Also, the patients initially continued previous immunosuppressive drugs during RTX treatment, and concomitant medications have been gradually withdrawn, which may also influence relapse rate.
Other factors besides personal characteristics at baseline may also influence relapse, such as important life events, treatment received and social stability factors.
However to add more confusion to this scenario, two recent studies have shown that H. pylori eradication does not influence relapse rates in GERD [ 16] and it may be even beneficial on symptomatic relapse in mild GERD [ 17].
Data from primary cancers suggest that NT5E may influence the anatomical site of relapse.
The worse association for overall survival in our study is not surprising, since the number of death events is smaller compared to relapse events and several further factors may influence the length of the time period between relapse and death.
If this is the case, cortisol may influence the motivation to drink and relapse via a potential negative-reinforcement pathway.
Different characteristics of the samples, different measures and additional variables such as further treatment or social network and support may influence the relationship between major depression and relapse.
A South African study reported significantly more treatment failures in the HIV-infected group suggesting that HIV infection may influence the response to treatment and the likelihood of relapse [31].
These fluctuations in androgens over the course of the day may influence the pattern of drug use and potential for relapse in men.
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