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However, certain genetic alterations that affect the expression or function of a key protein product, so called functional polymorphisms, may influence pathological processes either promoted or prevented by that key protein [16].
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These interactions can not only affect sterol and lipid metabolism, they may also influence pathological processes as diverse as Niemann-Pick C disease [8] and atherosclerosis [2].
The results suggest that Müller cells may aid in the local control of extracellular matrix deposition during retinal proliferative disorders, and that interaction of these cells with matrix-bound cytokine may influence their pathological behavior.
VEGF 1725A carrier may influence a pathological angiogenesis step after persistent HIF-1 activation.
We therefore hypothesize that the altered expression of Tspan12 in PBMCs may influence the pathological processes occurring in the failing heart, especially that tetraspanins are present not only on the plasma membrane but also in exosomes, which are often released by cells as messenger vehicles for intercellular communication [ 52].
Since α-synucleinopathy was reported in this case, although little is known about the relationship between α-synuclein and tau in AD, pathological processes involving α-synuclein may have influenced pathological progression in this patient.
These negative effects may influence the degree of pathological vessel formation in the RA synovium and hence the clinical response of RA patients on anti-TNFα treatment.
Although genetic factors may influence the dominance of pathological involvement to some extent (Al-Chalabi et al., 2012), 95% of patients report no family history of ALS or frontotemporal dementia, and currently have no obvious single genetic mutation that accounts for their disease despite indistinguishable clinical appearances.
Pathological microenvironment may influence the metabolic requirements for the maintenance of stem cell differentiation.
A variety of physiological and pathological changes may influence venous saturation and thus require different therapeutic interventions.
Because pathological changes may influence hip kinematics, we currently evaluate patients with hip diseases including osteoarthritis and femoroacetabular impingement using this technique.
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