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Early life factors may influence kidney growth and function throughout the life course.
In addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function.
Recently, Pattaro et al. (12) replicated the genetic association of serum creatinine levels with the MYH9 gene polymorphisms in European non-diabetic individuals, indicating that this gene may influence kidney function in non-Africans as well.
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Modifiable lifestyle-related factors are associated with risk of coronary heart disease and may also influence kidney disease risk.
Folate, vitamin B12, and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring.
We report global gene expression profiles of the kidney across the rat life cycle and the sex-specific changes that may influence normal kidney biology or underlie susceptibilities to adverse events.
The fact that AKI does not solely influence kidney function may have important implications for drug dosing, not only of renally eliminated drugs but also of those that are hepatically cleared.
Ma, J. et al. Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.
No clinical evidence is available however about whether these strategies may influence on long-term kidney outcome.
The inhibition of COX-2 in the kidney may influence fluid retention, which may in turn affect blood pressure and heart failure symptoms.
Such findings provide further evidence for a local tissue renin angiotensin system within the kidney which may influence regional function.
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