Finally, also the stiffness of the valve per se may influence the valvular interstitial cell phenotype, as demonstrated by studies of cells cultured on different matrices, in which substrates simulating the stiffer fibrosa layer (see above) are associated with an activated VIC phenotype and calcification.
A detailed description of nodal architecture, cell characteristics and interstitial fibrosis may influence the treatment choice or intensity of certain lymphoma entities.
The aetiology and severity of interstitial lung disease may influence the response to treatment.
Alternatively, microfluidic models in part allow in vivo relevant culture of human cells under physiological fluid shear stresses mimicking either the blood circulation or the interstitial extracellular fluid that may influence on the transport of NPs [18, 19].
Larger cancers may also have relatively poor blood supply and more pronounced gradients in interstitial pressure, hypoxia and acidity, which may influence tumour-cell sensitivity to therapy (Skipper, 1974) (Jain, 1990; Tredan et al, 2007).
Thus, despite IPF being a disease of peripheral lung, these observations raise the possibility that neurotrophins, generated by the pathological process of usual interstitial pneumonia, occur in more central airways where they may influence neuronal proliferation and differentiation.
This may influence their preference.
Genetic variability may influence hedonic hyperphagia.
Therapeutic interventions may influence hedonic eating behavior.
may influence the dependent variable.
