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While other factors such as TG export may influence hepatic lipid accumulation, we did not find a significant difference in the expression of hepatic microsomal triglyceride transfer protein (Mttp) between the groups although ApoB expression in the wild-type livers was significantly reduced when challenged with the HFD, a response not seen in the Tsc1−/− mice (Figure 9B).
No drugs that may influence hepatic blood flow were administered during the study period.
There are several factors, including alcohol intake, age, sex, BMI and smoking habit that may influence hepatic enzyme activity [ 53- 56].
Indeed, PNPLA3 retinyl-palmitate activity in hepatic stellate cells may influence hepatic regeneration and differentiation by altering availability of retinol, potent regulators of these phenomena [ 44].
Since the liver and intestine are connected anatomically and via the hepatic portal system, the gut microbiota and their metabolic by-products may influence hepatic pathology.
However the data in the present study do raise the possibility that, under certain circumstances, diets containing unsaturated fatty acids may influence hepatic detoxification systems.
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These data suggested that CD36 may negatively influence hepatic cholesterol and phospholipid efflux so this is enhanced in CD36 deficiency.
Therefore, carbohydrates with high and low glycemic index may differently influence hepatic fat deposition through a dissimilar influence on fatty acid synthetic pathways in the liver.
Liver function and liver blood flow can influence hepatic lactate clearance.
These gene polymorphisms may influence NAFLD via hepatic carbohydrate and lipid metabolism, protein modification or signaling pathways (Anstee and Day, 2013; Sookoian and Pirola, 2015).
A number of clinical factors may influence the activity of hepatic enzymes, including co-medications and liver disease.
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