Sentence examples for may influence effectors from inspiring English sources

Next, we sought to determine whether p53 activation may influence effectors that may instead inhibit mitochondrial biogenesis, such as HIF1 α.

Hence, the two populations of TStrC and MSC not only share several phenotypic features, but may influence effector cell populations such as NK cells in a similar way.

Other agents such as COX-2 inhibitors may serve to influence effectors of the inflammatory or wound responses that exert growth or survival effects towards tumour cells.

Because differences in GC sensitivity may influence immune effector functions, we examined whether these polymorphisms are associated with the susceptibility to develop Rheumatoid Arthritis (RA) and RA disease severity.

Furthermore, other genes may influence the terminal effector mechanisms at the motor endplates in muscle, or protect against them, for example, via complement regulators or rapsyn over-expression [ 20], though there are no clinical hints of hormone involvement at this stage.

Our observation that the GSH antioxidant pathway regulates pSTAT3Ser727 expression questions whether pSTAT3Ser727 effectors may influence ROS production.

In addition, a recent study showed that induction of TNFα responses may be important in the development of more effective B and T cell recall responses against influenza suggesting that a vaccine that enhances T cells with TNFα effector function may influence its ability to confer durable immunity [53].

While the notion that the timing of accumulation of pathogen-derived antigen/adjuvant may influence the kinetics of expansion of effector CD8+ T cells appears to be reasonable, few experimental models provide an opportunity to evaluate this important aspect of the CD8+ T cell response.

Nevertheless, one of these recently reported genes is involved in fibrosis: PPARG is an antifibrotic effector whose expression may influence the uncontrolled progression of fibrosis in SSc [ 32].

Consequently, in the mouse IL-21 is not essential for NK cell development, but it may influence their proliferation and their maturation into effectors cells.

For CDK2, Ire1, cSrc, EGFR and perhaps numerous other protein kinases that use αC-helix movement for conformational control, interactions with bound ligands in the ATP pocket may be strongly allosterically coupled to the inactive ↔ active transition and may influence the surface where these kinases bind external effectors.