Furthermore, factors such as compliance, intercurrent diseases/infections and lifestyle factors, including physical activity and diet, may influence dose demands of coumarins.
Besides being influenced by regulatory factors, the minimum daily dose accounts for additional factors that may influence drug effects such as genetics, ethnicity, diet, and environment.
Drug interactions may also influence dosing needs.
Lack of physical activity postoperatively may also influence dose requirements, since it has been shown that increased physical activity may lead to increased warfarin dose requirements in adults [ 33].
We are measuring other variables that may influence iron dosing patterns and effectiveness of iron therapy, including (1) the presence of inflammation or infection, (2) patient comorbidity, (3) use of other medications to treat anemia (i.e., erythropoiesis stimulating agents), and (4) patients' response to anemia therapy.
These may influence the dose that is delivered to the tumour and surrounding structures.
High adherence to therapy rate and low adverse effects of drugs to lower dose rate may influence secondary drug resistance.
Intriguingly, some evidence suggests that stress may influence the internal dose of a given toxicant.
Recently, it has been suggested that several factors such as physical activity, ventilation in the mines, dry or wet drilling may influence the individual doses (Marsh et al, 2008).
In summary, our findings are consistent with the previous studies that EPHX1 rs2292566 G>A polymorphism may influence the warfarin dose requirement, suggesting that translation of this knowledge into clinical guidelines may offer a useful and informative route to improve therapeutic management during warfarin therapy.
