Minimal inhibitory concentrations (MIC) can vary for these drugs and information on specific polymorphisms may influence dosing levels [ 48].
Lack of physical activity postoperatively may also influence dose requirements, since it has been shown that increased physical activity may lead to increased warfarin dose requirements in adults [ 33].
Drug interactions may also influence dosing needs.
These may influence the dose that is delivered to the tumour and surrounding structures.
We are measuring other variables that may influence iron dosing patterns and effectiveness of iron therapy, including (1) the presence of inflammation or infection, (2) patient comorbidity, (3) use of other medications to treat anemia (i.e., erythropoiesis stimulating agents), and (4) patients' response to anemia therapy.
Intriguingly, some evidence suggests that stress may influence the internal dose of a given toxicant.
In summary, our findings are consistent with the previous studies that EPHX1 rs2292566 G>A polymorphism may influence the warfarin dose requirement, suggesting that translation of this knowledge into clinical guidelines may offer a useful and informative route to improve therapeutic management during warfarin therapy.
Pautas et al. have identified EPHX1 rs2292566 G>A polymorphism as a novel predicting factor for variable warfarin response, reporting that alteration in the EPHX1 gene may change the pharmacokinetics and pharmacodynamics of warfarin exertion by inhibiting the activity of vitamin K epoxide reductase (VKOR), and thereby may influence warfarin maintenance dose [ 14].
It must be accepted that some interaction between the PTV and a PRV may be necessary, and may influence the prescribed radiation dose and dose distribution.
Recently, it has been suggested that several factors such as physical activity, ventilation in the mines, dry or wet drilling may influence the individual doses (Marsh et al, 2008).
