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This tumour-derived cytokine production may influence circulating plasma levels in NSCLC patients.
Furthermore, we did not perform a direct assessment of glomerular filtration rate, which may influence circulating RAGE levels.
Furthermore, laboratory mice are often anesthetized for blood sampling, which causes acute stress that may influence circulating cytokine concentrations and thus bias experimental results.
We can hypothesise that different SNPs in different regions of the VEGF gene may influence circulating levels of VEGF and thus response to anti-VEGF therapies.
These results from several different ethnic groups provide support for the notion that loci unlinked to the ACE gene may influence circulating ACE.
On the other hand, although experimental [ 20] and clinical [ 31, 32] data suggest that overweight and obesity may influence circulating DPP4 levels and activity, no associations of plasma DPP4a with BMI or obesity were found in the current study.
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Thus, the transcriptional activity of the resistin gene may also influence circulating adiponectin levels.
The consumption of inulin as a dietary supplement may also influence circulating AGE concentrations independently of its prebiotic function.
However, genetic variation in this locus may modestly influence circulating IGF-1 concentrations, at least at birth and during childhood.
In this report we have shown that there is strong evidence that there may be loci, unlinked to the ACE gene, which influence circulating ACE levels.
Although this disease spectrum reflects clinical reality, it may be associated with confounding factors unrelated to insulin sensitivity that could influence circulating MNA levels.
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