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Precipitating factors, such as sexual activity, may induce vascular changes with profound hemodynamic fluctuations, which may trigger the pain if an arterial narrowing is present.
Using gene profiling, we discovered that UFPs may induce vascular endothelial cells to express genes related to clotting.
Even modest overexpression of DYRK1A decreases NFATc protein activity and levels and may induce vascular and cardiac defects [ 33].
An unhealthy life style, diabetes, CVD and inflammation may induce vascular damage in the brain, which may also lead to depressive symptoms [ 10].
In the late 1980s, Furochgott and Zawadzki (1980) found that vascular endothelial cells produce a substance which may induce vascular smooth muscle relaxation.
Hyperglycemia-induced mechanisms that may induce vascular dysfunction in specific sites of diabetic microvascular damage include the following: 1. Increased polyol pathway flux.
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This interaction is particularly interesting in the light of recent observations indicating that in NO-deficiency other prostanoids (e.g. prostacyclin) may also induce vascular smooth muscle effects via activation of the thromboxane (TP) receptor [18] and cerebrovascular expression of TP-receptors is enhanced after SAH [19].
Silva [ 4] hypothesized that the release of inflammatory mediators such as tumor necrosis factor (TNF -alpha and inTNF -alpha(IL)-1 during andacute epinterleukinncreatIL -1may IL -1e widuringan vacutear episodelial injury.
Hemodialysis patients are exposed to continuous pulmonary insults of multifactorial origin, such as hormonal and metabolic derangement associated with end-stage terminal disease, which may induce pulmonary vascular alterations and consequent increased resistance.
Careful scrutiny of these factors may help elucidate the mechanisms that induce vascular dysfunction.
25– 27 Cryotherapy is believed to induce vascular damage that may lead to anoxia and ultimately tissue necrosis.
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