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In a previous study, neutralisation of IL-6 in human lung mast cell cultures significantly decreased the cell viability after seven days in normoxia [11], implicating that mast cells may induce their own survival in an autocrine/paracrine fashion.
Activation of Nrf2 and NF- κB involves regulation of protein kinases, which may induce their nuclear translocation [ 42].
LSCs share many characteristics with normal HSCs and inflammatory cytokines and signaling via cell contact-dependent receptors such as the TNFR CD27 may induce their expansion.
Moreover, when activated in stem/progenitor cells, p53 may induce their apoptotic death by stimulating pro-apoptotic proteins (like Bak proteins) or by the down-regulating anti-apoptotic factors (such as Bcl-2 and Bcl-xL) [ 14].
The seed genes were selected because they may be methylated aberrantly; thus, the abnormal methylation may induce their involvement in apoptosis and programmed cell death, affecting the development and progression of cancers [ 27, 28].
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Contrary to predictions from traditional financial theory, it is shown that investors may not induce their manager to allocate funds to the asset with the highest return.
For instance, CTL may kill through Fas pathway (Ostergaard et al, 1987; Rouvier et al, 1993), and granzymes entering target cells (Froelich et al, 1996; Jans et al, 1998; Pinkoski et al, 1998; Edwards et al, 1999) may rapidly induce their DNA fragmentation-based apoptosis (Heusel et al, 1994; Shresta et al, 1995).
As for the molecular mechanisms of the Arf6 pathway in invasion, we have shown previously that activation of Arf6 by GEP100, but not by other GEFs, perturbs E-cadherin-based cell-cell adhesion of breast cancer cells and may hence induce their motile phenotypes [ 23].
The studies presented in this section clearly suggest that, in the body, CSPGs expressions impose their functions and any mutation which appear at nucleotide sequence of CSPGs may induce changes in their functions.
In other cases, these drugs may induce alterations in their normal intestinal flora, mainly through the acquisition of antibiotic-resistant and/or pathogenic bacteria [5], [6].
Taking into account the previous considerations, further studies should be performed in order to delineate whether RCAS1 positive tumor cells may induce apoptosis to their surrounding tumor infiltrating lymphocytes.
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