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Classification according to symptoms is also inadequate because a causal agent may induce several different symptoms, even on the same plant organ, which often intergrade.
The external environmental stimuli may induce several cellular activities inside the tissue which in turn can vary tissue matrix.
On the other hand, in vitro the ΔF508 mutation does affect NBD1 folding [10], [13], [14] directly, suggesting that deletion of F508 may induce several folding defects, which eventually cause ER retention and degradation.
Progestins may induce several secondary effects such as breast tenderness, hirsutism, edema and unfavorable lipid profile modifications.
Although an appropriate tolerance, it may induce several adverse effects, such as fibro-interstitial pneumonitis due to the acquisition of activated myofibroblasts.
The pore-forming effect associated with the rapid collapse of the ΔΨm caused by cyclopalladated C7a, may induce several other modifications in mitochondria, such as uncoupling of ATP synthesis from oxidative phosphorylation and mitochondrial swelling [ 24].
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By means of NF-κB activation, oxidants may also induce several genes implicated in the inflammatory response [ 1, 2, 3, 4, 31, 32, 33, 34, 35, 36, 37, 38, 39] (Fig. 5).
Table 1 links this event (under the Hunan hypothesis) to Late-Pliocene (3.4 Ma) block faulting which may have induced several course changes along the proto-Mekong river [ 2] and the break up of connexions between Yunnan/Guangxi China and northern Thailand via the extended Mekong-Ping river, and flow reversals [ 20] in Northwest Sundaland.
Activating KRAS mutation in carcinoma cells may induce angiogenesis via several mechanisms.
A variety of animal models have been developed that aid in understanding the mechanisms that may induce one or several of the core features of autism (Ey et al. 2011; Hamilton et al. 2011; Tabuchi et al. 2007).
Since TGF-β may induce CTGF through several pathways, including SMAD, ras/raf/MEK/ERK, Ets-1, JNK, and protein kinase C, CTGF has long been thought to be an important mediator of its fibrotic effects [ 27- 30].
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