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NK cells may induce potent anti-leukaemic and possibly anti-rejection activity, and may even mitigate graft-versus-host disease (GvHD).
These promising results have encouraged researchers to refocus on the studies of structure, function, antigenicity, and immunogenicity of gp120 in order to identify the critical functional regions containing relatively conserved neutralizing epitopes that may induce potent and broadly cross-reactive neutralizing antibodies.
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These vaccines can induce potent neutralizing and protective responses in immunized animals but may induce antibodies that enhance infection by early human SARS-CoV and animal SARS-CoV like viruSARS-CoV like
The ability of DNA to induce potent and cross-reactive immune responses against influenza in primates is of considerable interest and may provide a useful tool to influenza prevention efforts.
With their ability to induce potent innate and adaptive immune responses and to deliver antigen to intracellular processing and presentation pathways, rAd vectors may be particularly well suited for vaccination against viruses and other intracellular pathogens.
The extract could also induce potent hypoglycaemia in STZ induced diabetic rats.
Synthetic bacterial DNA and viral dsRNA CpG***, Poly I C* PAMP, TLR pathway, induce potent humoral and cellular immunity.
Vaccines need to stimulate DCs to induce potent immune responses.
Nasal immunisation has long been reported as one of the most effective routes to induce immune responses in the female genital tract 3. It is easily accessible, may be more culturally accepted than the vaginal or rectal routes of immunisation, requires lower amounts of antigen to induce immune response, and has the ability to induce potent responses both in serum and mucosally 4.
Some of these organic substances are potent irritants and may induce delayed allergic reactions.
Receptor activator of nuclear factor kappa-B ligand (RANKL), robustly induced at 4 weeks, has direct mitogenic activity in mammary epithelial cells and, as a potent inducer of NF-κB activity, may induce inflammatory genes.
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