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Predictions show that heavily loaded GFBs comprising two bump layers in series and including stop pins prevent too large bump deflections which may induce permanent plastic deformations.
Figure 2 suggested that fetal hormonal environment may induce permanent changes in adult glucose homeostasis without altering adiposity in mice.
There is retraction and demyelination of spared axons which may induce permanent loss of sensorimotor functions that is unresponsive to treatment [ 21].
Based on the physical interaction between HESX1 and DNMT1 shown in the present study, we postulate that HESX1 may induce permanent gene silencing by an additional mechanism of action, namely the specific methylation of CpG residues of HESX1 target genes.
Reproductive factors may induce permanent changes in the mammary gland epithelium or surrounding stromal tissue, and the most prominent effects may be related to the occurrence and timing of pregnancy [ 15, 16].
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Immune therapy may lead to an increased tolerance threshold for CMP with persisting CMA [ 39] and may even induce permanent tolerance to CMP [ 37].
Both animal and epidemiologic studies indicate that nutrition and environmental stimuli influence in utero developmental pathways and may even induce permanent changes in metabolism and chronic disease susceptibility (McMillen and Robinson 2005).
This suggests that the LVAD may induce some permanent structural damage in the kidney.
Pattern vision deprivation (BD) can induce permanent deficits in global motion perception.
In contrast, developmental exposure to MeHg did not induce permanent auditory deficits.
Interference at any one of these stages of development would be expected to induce permanent impairment.
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