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In this regard, some important mitochondrial proteins have been identified as substrates of calpain-1, such as ATP5A1 [ 46], optic atrophy-1 [ 47], apoptosis-inducing factor [ 48], etc. Disruption of these mitochondrial proteins may induce mitochondrial dysfunction and excessive ROS generation.
Take together, the findings indicated that simulated microgravity may induce mitochondrial related apoptosis of UT-7/EPO cell through depressing the EPO EPOR pathway.
In view of NaBt-mediated increase in mitochondrial population, we hypothesized that NaBt may induce mitochondrial biogenesis via mitochondrial DNA (mt-DNA) metabolism.
Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism.
This indicates that PEG-AuNPs may induce mitochondrial dysfunction and influence the intrinsic apoptosis pathway.
Furthermore, endotoxin may induce mitochondrial structural alterations, leading to oxygen waste through the inner mitochondrial membrane [ 9, 11].
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ROS may also induce mitochondrial dysfunction and cellular apoptosis [ 15].
This result suggests that C7a may also induce mitochondrial permeabilization by catalyzing the cross-linkage of vicinal thiol groups present in the mitochondrial membrane proteins with the formation of disulfide bonds.
Nucleoside-derived drugs, particularly those used in antiviral therapy, may induce severe mitochondrial toxicity [ 28, 29].
Downregulation of these microRNAs, in particular hsa-miR-9, may prompt inflammatory signaling and induce mitochondrial oxidative stress, resulting in photoreceptor cell death and consequential vision loss in sympathetic ophthalmia [52].
This may be correlate with its capacity to induce mitochondrial membrane depolarization.
More suggestions(15)
may induce unnecessary
may suggest mitochondrial
may involve mitochondrial
may induce bacterial
may regulate mitochondrial
may maintain mitochondrial
may augment mitochondrial
may perturb mitochondrial
may restrict mitochondrial
may be mitochondrial
may indicate mitochondrial
may promote mitochondrial
may induce neuromuscular
may modify mitochondrial
may induce severe
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