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Regional, mainly liver-directed, therapies may induce limited tumor responses but do not improve overall survival.
In addition, the development of targeted drugs, which may induce limited tumour response, demands phase II trial designs which both minimize resource use and are sensitive and specific to signals of drug activity [ 4].
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The significant reduction in free LOS may also be the main cause of the Plow induced limited inflammatory response and consequently the reduced fever after vaccination (Fig. 3).
If such alterations are indeed induced by androgen withdrawal, they may have limited relevance to first-line patient therapy.
Rather CHOP levels were decreased in DTg animals (Fig. 5A), implying that overexpression of RNF5 may induce ER stress by limiting the activation of some UPR components.
Foam may induce cell death, and may limit the performance of down-stream processing steps.
Moreover, they are particularly advantageous over CLECs in which substrate or products may induce internal diffusional resistances that limit the reaction rate.
As recoding the negative values to the minimum detectable limit may induce bias and reduce efficiency in the statistical analyses, KXRF-measured bone lead concentration estimates were used in the analysis without recoding (Kim et al. 1997).
Our results suggest that fishing with either size-limit may induce considerable changes in life-history trait expression (maturation schedules and growth rates), recruitment, and population abundance and structure.
It is suggested that local high densities may induce competition only when resources are limited.
This could be because the analysis of complete cases has limited power and may induce bias if missing values are related to covariates of interest, whereas under the missing-at-random assumption, multiple imputation corrects biases observed with complete case analysis [ 49] and increases power.
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