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Even brief overfeeding may induce insulin resistance [ 29].
Indeed, there is evidence that periodontitis may induce insulin resistance [ 18].
Chemerin is a rather novel adipokine that regulates adipogenesis and may induce insulin resistance [ 46, 47].
BPA produces down-regulation of glucose transporters in adipocytes (Sakurai et al. 2004), an action that may induce insulin resistance.
Recently it has been speculated that hypothermia may induce insulin resistance leading to hyperglycaemia possibly promoting infection onset [ 8, 13].
Proinflammatory cytokines, such as tumor necrosis factor (TNF -α, may induce insulin resisTNF -αby binding to insulin-responsive elemayts induceletal muscle (10).
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Stress may also induce insulin resistance in adipose tissue, liver and heart [ 120].
Firstly, the 64Arg variant of the β3-adrenergic receptor (ADRB3) gene - which may also induce insulin resistance through reduced lipolysis and increase in adipocytes, thus possibly providing an explanation for the link between these facets of the metabolic syndrome [ 48].
The alternative hypothesis implies that secretion of adipokines may induce hepatic insulin resistance (9).
Aging is characterized by progressive impairment of carbohydrate intolerance and is usually accompanied by physical inactivity and obesity, which may induce hyperinsulinemia, insulin resistance, and cardiovascular disease (1).
Since the hypoglycemic effect of GJ is similar to that of thiazolidinediones, GJ may be able to induce insulin sensitivity and prevent DM development.
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