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Finally, prophylaxis with passive (HBsAb) or even active (HBsAg) immunization may induce immune escape mutations in the YMDD region and may simultaneously lead to the emergence of drug resistance even in previously untreated patients.
Autoantibody responses to p53 will require appropriate primary immunization; initial low-dose antigen exposure may induce immune tolerance and lack of response.
This observation indicates that immunization with a truncated form of a gene may induce immune modulation, a phenomenon that should be taken into account for the design of vaccines.
Since CTLA4-Ig mediated co-stimulatory blockade induces remission of autoimmunity, we sought to determine whether a temporary suppression of CD40 expression by administration of siRNA may induce immune modulatory effects on RA that predispose towards reduction of immunity towards the autoantigen.
Many experimental SHIV stocks contain a large proportion of replication-defective, non-infectious, or severely attenuated virions; these may induce immune responses by this mechanism.
Initial low-dose antigen exposure may induce immune tolerance and lack of response.
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Interestingly, other recent studies have confirmed that epicutaneous immunization may induce immune-regulatory networks with potential therapeutic advantages [36], [37].
We therefore suggest that, as opposed to generating an immunosuppressive population, tumours such as 4T1 may simply induce immune dysregulation, promoting neutrophil activation to inhibit adaptive anti-tumour immune responses.
The anti-inflammatory effects of sericin [27] may also induce immune reactions upon physical association with fibroin-silk fibers [28].
Protein-conjugated vaccines, which induce T cell-dependent immune response, may induce superior immune responses compared with the polysaccharide vaccine.
Many genes of the adaptive immune response that were up-regulated may function to induce immune tolerance to the embryo, while genes of the innate immune response (in particular, antimicrobial genes) may function to protect the uterus against infection during a time of local immune suppression.
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