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When effective, such T cells are capable of eradicating neoplastic cells prior to tumor formation.2,3 Notably, when combined with standard surgical, radiologic and chemotherapeutic treatments, immune-based interventions may induce durable T-cell responses capable of eliminating cancer stem cells inhibiting metastasis and disease recurrence.
Our results show that NST is feasible, and may induce durable responses in subsets of patients, even in the presence of extensive, bulky disease.
doi: 10.1038/sj.bjc.6600437 www.bjcancer.com © 2002 Cancer Research UK Manipulating the immune system by interleukin-2 (IL-2) based immunotherapy may induce durable tumour regression in metastatic renal cell carcinoma (mRCC) (Minasian et al, 1993; Fyfe et al, 1995; Jeal and Goa, 1997; Bordin et al, 2000; Fisher et al, 2000; Negrier et al, 2000).
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In conclusion, immune therapy of melanoma is by 2013 an established and expanding strategy that can induce durable responses in advanced-stage melanoma patients, some of whom may be cured for life.
Agonists of the stimulator of interferon genes (STING) pathway, which trigger innate immune activation, can induce durable antitumor responses.
Several cancer vaccine approaches induce durable CD4+ T cell responses and have promising clinical activity.
In summary, these immunogens have low adverse reactogenicity and induce durable antibody and T cell responses to the prototype strains.
Integrase defective lentiviral vectors (IDLV) represent a promising vaccine candidate given their ability to induce durable and protective immune responses in mice after a single immunization.
Fine particles, which may carry toxic chemicals of carcinogenic potential (Laden et al. 2000), can reach lung alveoli where the clearance is slow (Pinkerton et al. 1995) and induce durable pulmonary and systemic inflammation (Riva et al. 2011).
It was also shown to induce durable remissions (median 26 months).
Unlike many other viruses, infection with RSV does not induce durable protective immunity.
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