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Simultaneously, increased BMP signaling and up-regulation of FOSL2, EIF4A and RPS23 combined with ATF5 and NKX3.2 down-regulation, may induce differentiation [18], [59] [62].
The inhibition for those tumor-associated mutant IDH proteins may induce differentiation of those cancer cells.
This suggests that hedgehog pathway may induce differentiation of prostate stem/progenitor cells into CD44/P63 hyperplasia basal cells [ 112].
Recent animal studies suggest that prepubertal oestrogen exposure may induce differentiation and thus eliminate targets for malignant transformation [ 17].
DHEA is also known to activate peroxisome proliferator-activated receptor (PPAR -α and PPAR -α which mandinduce differentiation and inhibit carcinogenesis [ 7].
Thus, although Klf2 in epiSCs may induce differentiation upon transfer to LIF-Stat3, such tendency is blocked efficiently by Prdm14 and may contribute to fast and efficient reprogramming.
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Interestingly, IGF-1Ea overexpression decreased GATA4 upregulation (Fig. 3D) compared to differentiated control cells, suggesting that this specific IGF-1 propeptide may induce cardiomyogenic differentiation by regulating the expression of the early mesodermal and endodermal markers.
These data suggest that Epo may induce BMSC differentiation towards an osteoblastic phenotype.
Nevertheless, the mechanism by which TPA may induce megakaryocytic differentiation remains to be further addressed.
Moreover, we substantiate that Hox-C9 may induce neuronal differentiation in a fraction of neuroblastomas.
For example, IL-23 may induce the differentiation of naive T cells into highly pathogenic Th17 cells.
More suggestions(15)
may block differentiation
may induce anxiety
may represent differentiation
may induce pain
may impede differentiation
may allow differentiation
may permit differentiation
may exaggerate differentiation
may require differentiation
may influence differentiation
may induce novel
may induce overcorrection
may induce weight
may impair differentiation
may induce tumor
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