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Moreover, M1-siRNA may indirectly result in reduced virus replication, thus affecting caspase-9 activation.
We suggest that PIN may indirectly result from the deregulation of pro-inflammatory pathways following PPARγ inactivation combined with extension of life span via increased autophagic capacity.
In our previous studies, we confirmed that PLA2G4A was overexpressed in POF ovaries and hypothesized that upregulation of PLA2G4A may indirectly result in the occurrence and development of POF by increasing prostagl and in concentration.
In our study, the fixed effect of survival of the back neighbours was excluded because this effect may indirectly result from the focal cage itself; if a back neighbour effect exists, then mortality in the focal cage will affect mortality of back neighbours, and vice versa, creating a feedback loop.
At least two models could explain this suppression: first, pom152 ∆ might act as a "dosage suppressor" by freeing factors from the NPC that are involved in both NPC and SPB assembly, and second, reduced NPC assembly in pom152 ∆ may indirectly result in NE changes that allow SPB duplication in the absence of MPS3 (Jaspersen and Ghosh 2012).
This may indirectly result into prescribing coxibs plus GPAs, even if in Italy this represents an unlicensed use, and despite lacking evidence from RCTs on the higher safety profile of this combination compared to coxib alone or to traditional NSAIDs plus GPAs.
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The new proton transfer in H166L may directly or indirectly result in partial protonation of one of the remaining His residues, even though that residue is not protonated in the wild type.
Moreover, this two-hybrid interaction may have indirectly resulted from post-translational Smt3 modification of Red1 itself or some other Red1 binding protein.
Because post-Golgi vesicles rely on dynamic polymerization of actin MF for their motility and possibly for their directionality in root hairs [ 24, 28], the disrupted actin MF network due to 2-BP may have indirectly resulted in the impaired secretion.
Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification.
Obesity and insulin resistance [2] may therefore in fact indirectly result in the increase in hepatic oleate synthesis via chain elongation of circulating palmitate in high fat-fed mice.
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